Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4
Localized activation of signaling is required for proper cell migration. Phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger 1 (P-Rex1) is a Rho guanine-nucleotide exchange factor (RhoGEF) abundantly expressed in neutrophils that …